Angel & Pre-Seed Investments

Investing in early-stage biotech with durable conviction.

PC&H is a specialized investment firm focused on technically differentiated biotechnology startups. We partner with founders through key inflection points.

Stage
Angel → A
Style
Founder First

Nanoparticle Technologies

Nanoparticles are revolutionizing drug delivery, diagnostics, and therapeutics. We're particularly excited about lipid nanoparticles (LNPs), polymeric systems, and inorganic nanocarriers.

💊
Drug Delivery

LNPs, exosomes, and targeted carriers for RNA and gene therapies

🎯
Targeted Therapeutics

Tumor-targeting nanoparticles and tissue-specific delivery

🔍
Nano-Diagnostics

Quantum dots and contrast agents for imaging and detection

Medical Technology

We back innovative medical devices and technologies that improve patient outcomes, reduce healthcare costs, and transform clinical practice.

🏥
Medical Devices

Implantables, surgical robotics, and next-gen diagnostics

📡
Remote Monitoring

Wearables, continuous sensors, and connected health platforms

Surgical Innovation

Minimally invasive tools and AI-assisted procedures

Aging & Longevity

We're excited about the science of aging and companies working to extend healthspan. From senolytics to cellular reprogramming, this field is poised for breakthroughs.

🧬
Cellular Rejuvenation

Reprogramming, senolytics, and mitochondrial therapies

🔬
Aging Biomarkers

Epigenetic clocks, proteomics, and biological age testing

💪
Healthspan Extension

Interventions targeting age-related decline and disease prevention

Focus visualization
🧬

Therapeutics

Biologics, small molecules, cell and gene therapies with clear paths to clinical proof.

⚙️

Platform Biotech

Repeatable discovery engines and scalable production technologies.

🤖

AI × Healthcare

Machine learning for drug discovery and clinical decision support.

🏥

Medical Devices

Innovative devices and surgical technologies improving outcomes.

🔬

Diagnostics

Point-of-care testing, liquid biopsy, and precision medicine tools.

💻

Digital Health

Remote monitoring and software that improves care delivery.

What We Look For

Clear scientific hypothesis supported by early evidence
Credible path to value-defining milestones
Strong technical leadership and thoughtful governance
Development realism (regulatory, CMC, clinical)
Capital discipline without compromising rigor
Teams that communicate clearly and learn quickly